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Mass Spec and Proteomics > Our Staff

 


Arpad Somogyi
Arpad Somogyi, PhD - Associate MS&P Facility Director - somogyi.16@osu.edu - Publications (PDF)
As the Associate Director of the CCIC MS&P Facility, I oversee the day-to-day operation, generate proposals for additional new instruments and upgrades, and interact with faculty, posdocs and students to ensure that their analytical needs are met in the most efficient way possible. I enjoy consulting with colleagues from different research areas. I have many years of experience in mass spectrometry. Specifically, my main interest include studying peptide fragmentation mechanisms, gas-phase H/D exchange, synthetic polymer analysis, astrobiological applications, biological, biochemical and proteomic applications. I have been working with wonderful colleagues on many exciting research areas, the results of which are summarized in 104 peer reviewed publications.



Liwen Zhang
Liwen Zhang, PhD - Technical Director for Proteomics - zhang.287@osu.edu - Publications (PDF)
I am the Technical Director for OSUCCC Proteomics Shared Resources (PSR) at the CCIC/MS&P Facility. I work extensively in the identification of proteins, protein-protein binding partners, post-translational modifications, crosslink oramino acid mutation of proteins, as well as label-free or isotope-labeling protein quantitation using mass spectrometry coupled with chromatography. I have almost 20 years of experience with many aspects of mass spectrometry and have been working in the facility for 17 years. I am responsible for the daily operation of the OSUCCC Proteomics Shared Resources. Working together with other colleagues, we provide consultant for experiment design, sample preparation, LC-MS/MS analysis, data analysis/interpretation and assist for publications or grant submission. I also participate in teaching and promoting mass spectrometric education by training graduate students on Orbitrap operation and demonstrating MS experiments to graduate and college students. My collaboration with the facility users has led to almost 50 peer-reviewed publications, one book chapter, and two pending US patents. I completed my graduate research at The Ohio State University under the supervision of Dr. Michael A. Freitas (currently at The Ohio State University).



Nan Kleinholz
Nan Kleinholz, BS - Senior Research Associate - kleinholz.1@osu.edu
I am the Instrument Coordinator of the the CCIC MS&P Facility. I have worked in MS&P since 2000 and have combined laboratory experience of 27 years. I am in charge of ensuring the safe and optimal operation of the ESI and MALDI mass spectrometers and HPLC’s. I perform routine maintenance and repair as necessary. I conduct complex and independent experimentation within the MS&P. I counsel and advise our customers on experiments and data analysis. I also train staff and self-operation users.



Sophie Harvey
Sophie Harvey, PhD - Research Associate 2 - harvey.486@osu.edu
I work on proteomics samples within the OSU Mass Spectrometry and Proteomics Facility. This includes identifying proteins using bottom-up approaches and top-down approaches as well as intact protein or protein complex measurements. I work on identifying post translational modifications, as well as label-free or isotope labelled samples for quantitation. My work mostly uses the Thermo Orbitrap Fusion, Thermo Q Exactive Plus, Thermo Orbitrap XL instruments, and the 15T FT ICR MS. My role also includes data analysis of these samples using a variety of different software packages-including Mascot and Proteome Discoverer. Prior to working in the facility I received my PhD from the University of Edinburgh working under the supervision of Perdita Barran, using MS and ion mobility-MS to study conformationally dynamic proteins and their interactions with small drug molecules or biomolecules. Following this I did postdoctoral research in the lab of Vicki Wysocki at The Ohio State University studying the structure of protein complexes, and membrane protein complexes, using MS and IM-MS.



Matt Bernier
Matthew Bernier, PhD – Research Associate 2 - bernier.19@osu.edu
I am the small molecule, accurate mass, and metabolomics facilitator here at the Mass Spectrometry and Proteomics Facility. My work here at the facility began in early 2017 after first finishing my PhD with Vicki Wysocki at OSU in 2014 and doing Post-Doctoral work at Georgia Tech with Dr. Facundo Fernandez. My main research areas of focus have mainly involved small molecule peptide fragmentation fundamentals, ambient ionization development, and high-resolution analysis. I have experience working with small molecule analysis of complex mixtures from many sources and have used many instrument platforms from GCMS to ICR along with small molecule analysis with ion mobility on Waters Synapt G2 instrumentation. In the facility, I use mainly the ThermoScientific Quantiva triple quadrupole for targeted metabolomics and the Thermo Q-Exactive plus for untargeted metabolomics for the majority of projects. I also train users in the operation of the triple quadrupole, the GCMS Thermo DSQ instrument, and run accurate mass analysis on our 15 T Bruker ICR. In addition, for both targeted and untargeted small molecule metabolomics I use our data analysis programs, particularly Progenesis and other open source software, to identify targets of interest and perform the appropriate statistical analysis for the highest quality data for submitted projects.



Andrew Reed
Andrew Reed, PhD – Research Associate 2 - reed.1287@osu.edu
I am biochemist by training, who focuses on the protein biochemistry aspect of proteomics research. This largely includes advising or performing preparation of protein samples for mass spectrometry experiments. I have extensive experience with cloning and protein construct design, protein expression in bacterial and eukaryotic (insect cells) systems, and protein purification. Prior to working at the CCIC, I received my PhD from The Ohio State University while studying under the guidance of Dr. Zucai Suo, where I performed structural and biochemical characterization of enzymes related to DNA replication and repair. Through this work I have gained extensive experience in protein production, as well as enzyme kinetics. In addition, I have a great understanding of protein complex interactions (protein-protein and/or protein-DNA/RNA) and their associated dynamics.


 


Miranda Garnder
Miranda Garnder, PhD - Researcher 2 - gardner.207@osu.edu
Here at CCIC-MSP, my work focuses on development and implementation of proteomics pipelines with open-source software to analyze label-free and labeled bottom-up proteomics samples with an emphasis on data exploration (normalization, statistical tests, and data visualization). Prior to working in the facility, I received my PhD from The Ohio State University under the guidance of Dr. Michael Freitas where I utilized MS and ion-mobility MS to study how mutational status of histone modifying enzyme EZH2 contributes to diffuse large b-cell lymphoma (DLBCL).


 


Gong Wu
Gong Wu, PhD - Researcher 2 - wu.348@osu.edu
I have extensive experience in natural products, protein and organic chemistry, drug design, development and validation. My role in the CCIC MSP facility is to design metabolomics experiments for targeted and non-targeted analysis by HPLC/MS/MS, sample preparation, data acquisition, data analysis including quantitation of targeted components in samples, metabolite identification, statistical analysis of data sets, bioinformatics, and pathway analysis.


 


Alison Horrox
Alison Horrox - Business Operations Administrator - horrox.1@osu.edu
I oversee all administrative functions of the Center to assist the CCIC & Campus Microscopy and Imaging Facility (CMIF) management teams. This role is responsible for fiscal, procurement, customer billing, policy development, grant administration, and travel coordination activities within the units; I also provide fiscal analysis to the Director and Associate Directors for planning purposes, while developing, tracking, and analyzing unit budgets. Finally, I serve as the primary fiscal contact for internal and external customers.