Our NMR facility features nine high-resolution Bruker spectrometers (600-1200 MHz) equipped with advanced capabilities: high sensitivity cryoprobes for biomolecular studies, high throughput sample changers for metabolomics, and solid-state probes for biomolecules and materials. Available to scientists within and beyond Ohio State, our facility advances research through:
- Determination of atomic resolution three-dimensional structures of important biological macromolecules in solution and solid state
- Investigation of molecular motions from picoseconds to seconds and beyond that are important for understanding their functions
- Unravel the underlying mechanism of biological function from molecular to atomic level
- Characterization of protein-protein, protein-DNA and protein-small molecule interactions
- Discovery and development of new and improved drugs
- Evaluation of newly synthesized small-molecules and isolated natural products
- And more
